Association of body mass index with long-term outcomes after elective and semi-urgent percutaneous coronary intervention

Abstract Background While obesity is associated with cardiovascular mortality and morbidity, patients higher body mass index (BMI) may have better outcomes post-percutaneous coronary intervention (PCI). This “obesity paradox” controversial needs clarification. Purpose We aimed to investigate the relationship between BMI post-PCI in an Asian cohort. Methods A retrospective cohort study was performed on consecutive who underwent semi-urgent PCI for non-ST elevation myocardial infraction or unstable angina, elective stable angina from January 2014 December 2015 a tertiary centre. Patients were underweight (BMI <18.5), normal weight 18.5–22.9), overweight 23–24.9), pre-obese 25–29.9) obese ≥30), according WHO classification. The primary endpoint all-cause mortality. secondary subsequent events of stroke transient ischemic attack, infarction (MI) congestive cardiac failure (CCF). Results 1,610 followed up 3.71 (±0.97) years, 19.7% female mean age 62.1 years (Table 1). showed U-shaped incidence death (p<0.001), MI (p=0.005), CCF (p<0.001) (Figure 1A), which also shown Kaplan Meier analysis (Figures 1B-E). With reference multivariable Cox analysis, (adjusted HR 0.64, 95% CI 0.42–0.97) 0.55, 0.38–0.80) had lower Underweight risk 2.12, 1.01–4.46), while 0.56, 0.34–0.92) compared patients. (underweight: adjusted 3.05, 1.45–6.42; obese: 1.86, 1.03–3.35) Conclusion at upper extremes demonstrated mortality, post-PCI. Funding Acknowledgement Type funding sources: None.